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Methods Mol Biol. 2007;368:15-38.

The principles of freeze-drying.

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1
Lyosolutions, Salisbury, Wiltshire, UK.

Abstract

This chapter provides an up-to-date overview of freeze-drying (lyophilization) with particulars relevance to stabilizing live cells or viruses for industrial applications as vaccines or seed culture. The chapter discusses the importance of formulation, cycle development, validation, and the need to satisfy pharmaceutical regulatory requirements necessary for the commercial exploitation of freeze-dried products.

PMID:
18080460
DOI:
10.1007/978-1-59745-362-2_2
[Indexed for MEDLINE]

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