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Exp Eye Res. 2008 Feb;86(2):171-7. Epub 2007 Nov 5.

Pericytes and ocular diseases.

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1
Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA.

Abstract

Pericytes are vascular mural cells which play multiple roles in angiogenesis and maintenance of blood vessel morphology and stability. In this review, we analyze recent data on the participation of pericytes in the pathogenesis of proliferative and non-proliferative diabetic retinopathy, as well as an emerging role in other angiogenic ocular diseases such as retinopathy of prematurity. Ways to exploit pericytes as targets for treatment of ocular diseases are discussed.

PMID:
18078933
DOI:
10.1016/j.exer.2007.10.013
[Indexed for MEDLINE]
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