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Biol Psychol. 2008 Sep;79(1):103-10. Epub 2007 Nov 1.

DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia.

Author information

1
Feinstein Institute for Medical Research, Manhasset, NY, USA. szeszko@lij.edu

Abstract

BACKGROUND:

DISC1 is considered a susceptibility gene for schizophrenia and schizoaffective disorder, but little is known regarding the potential mechanisms through which it may confer increased risk. Given that DISC1 plays a role in cerebral cortex development, polymorphisms in this gene may have relevance for neurobiological models of schizophrenia that have implicated cortical deficits in its pathophysiology.

METHODS:

We investigated whether the DISC1 leu607phe polymorphism was associated with prefrontal gray matter volumes using magnetic resonance imaging in a cohort of patients with schizophrenia (N=19) and healthy volunteers (N=25) and positive and negative symptoms in 200 patients with schizophrenia.

RESULTS:

Among patients and healthy volunteers, phe carriers (N=11) had significantly less gray matter in the superior frontal gyrus and anterior cingulate gyrus compared to leu/leu homozygotes (N=33). Further, among patients left superior frontal gyrus gray matter volume was significantly negatively correlated with severity of hallucinations. In addition, patients who were phe carriers (N=144) had significantly greater severity of positive symptoms (hallucinations) compared to patients who were leu/leu homozygotes (N=56).

DISCUSSION:

These findings implicate DISC1 in variation of prefrontal cortical volume and positive symptoms, thus providing a potential mechanism through which DISC1 may confer increased risk for schizophrenia or schizoaffective disorder.

PMID:
18078707
PMCID:
PMC2623247
DOI:
10.1016/j.biopsycho.2007.10.011
[Indexed for MEDLINE]
Free PMC Article

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