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Ugeskr Laeger. 2007 Nov 12;169(46):3971-4.

[Quadrivalent HPV 6/11/16/18 vaccine].

[Article in Danish]

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Rigshospitalet, Juliane Marie Center, Kraeftens Bekaempelse, Institut for Epidemiologisk Kraeftforskning, Aalborg Sygehus.


This randomized, double-blind study included 12,167 women who received three doses of quadrivalent HPV 6/11/16/18 vaccine or placebo (day 1, month 2, and month 6). The participants were followed for an average of 3 years. The vaccine prevented 98% of CIN2, CIN3 and adenocarcinoma in situ related to HPV 16 or HPV 18 among women not previously exposed to these types, and 44% among all women (i.e. both those with and without previous infection). The vaccine efficacy against all high-grade cervical lesions, independent of causal HPV type, was estimated to 17%.

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