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Sex Transm Dis. 2007 Dec;34(12):954-9.

Longitudinal association between hormonal contraceptives and bacterial vaginosis in women of reproductive age.

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National Institutes of Health, Rockville, Maryland, USA.



This study examined whether hormonal contraceptive use is associated with diagnosis of bacterial vaginosis (BV) over 1 year.


A total of 3,077 women of reproductive age were recruited from gynecologic and family planning clinics for a 1-year prospective longitudinal study. Data collected over 5 visits included demographics, health and hygiene behaviors, and gynecological exams. Gram stains were used to quantify vaginal flora.


There was a decreased risk of overall BV prevalence among oral contraceptive users (odds ratio, OR 0.76; confidence interval, CI 0.63-0.90) and among those using hormonal injection/implant (OR 0.64; CI 0.53-0.76). An increased risk for BV prevalence (OR 1.38; CI 1.11-1.71) and incidence (OR 1.43; 1.02-2.07) was observed among those subjects who had tubal ligation. Greater remission of BV was found among those using hormonal injection or implant (OR 1.67; CI 1.23-2.27) whereas less remission occurred among those subjects who had tubal ligation (OR 0.56; CI 0.39-0.80).


Hormonal contraceptive use is associated with a decreased risk of BV.

[Indexed for MEDLINE]

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