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J Virol. 2008 Feb;82(4):2028-32. Epub 2007 Dec 12.

H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44.

Author information

1
Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

Abstract

Antiviral immune defenses involve natural killer (NK) cells. We previously showed that the NK-activating receptor NKp44 is involved in the functional recognition of H1-type influenza virus strains by NK cells. In the present study, we investigated the interaction of NKp44 and the hemagglutinin of a primary influenza virus H5N1 isolate. Here we show that recombinant NKp44 recognizes H5-expressing cells and specifically interacts with soluble H5 hemagglutinin. H5-pseudotyped lentiviral particles bind to NK cells expressing NKp44. Following interaction with target cells expressing H5, pseudotyped lentiviral particles, or membrane-associated H5, NK cells show NKp44-mediated induced activity. These findings indicate that NKp44-H5 interactions induce functional NK activation.

PMID:
18077718
PMCID:
PMC2258730
DOI:
10.1128/JVI.02065-07
[Indexed for MEDLINE]
Free PMC Article
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