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Expert Rev Anticancer Ther. 2007 Dec;7(12 Suppl):S79-85. doi: 10.1586/14737140.7.12s.S79.

Convection-enhanced delivery for treatment of brain tumors.

Author information

1
The University of Chicago Hospitals, Section of Neurosurgery, MC4066, 5841 South Maryland Avenue, Chicago, IL 60637, USA. sherise@uchicago.edu

Abstract

Recently, innovative therapies have been developed for the treatment of malignant gliomas. Unfortunately, adequate delivery of these therapies has been a major obstacle to clinical success. Intravenous administration is restricted by the presence of the blood-brain barrier while local delivery, such as with drug-impregnated wafers, results in limited parenchyma penetration. Convection-enhanced delivery is a promising method for the delivery of macromolecules to the CNS. Convection-enhanced delivery involves the infusion of therapeutic agents via surgically implanted catheters and uses a pressure gradient to achieve a greater volume of distribution compared with that seen with diffusion alone. This article will review the development of convection-enhanced delivery and its use in the treatment of malignant gliomas.

PMID:
18076322
DOI:
10.1586/14737140.7.12s.S79
[Indexed for MEDLINE]

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