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Autoimmunity. 2007 Dec;40(8):582-90.

PTPN22: its role in SLE and autoimmunity.

Author information

1
Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, CA, USA.

Abstract

A functional variant of protein tyrosine phosphatase nonreceptor 22 (PTPN22) has recently been shown to be associated with multiple autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, type 1 diabetes, and autoimmune thyroid disease. In this review, we discuss the structure and function of this gene and its disease-associated polymorphisms. In addition, we review the studies investigating the association between this gene and SLE, along with other autoimmune diseases.

PMID:
18075792
PMCID:
PMC2875134
DOI:
10.1080/08916930701510848
[Indexed for MEDLINE]
Free PMC Article

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