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Autoimmunity. 2007 Dec;40(8):550-9.

General aspects of the genetics of SLE.

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1
Department of Molecular Genetics and Rheumatology, Imperial College, London, UK.

Abstract

The application of genetic techniques to the study of systemic lupus erythematosus (SLE) has identified candidate genes with diverse immunological function. There is a growing understanding that susceptibility to SLE is due to a complex interaction of multiple genes and environmental factors, and that many of these may be shared with other autoimmune diseases. In this first of a series of review articles we outline our current understanding of SLE genetics, in particular summarising the results of recent association studies.

PMID:
18075789
DOI:
10.1080/08916930701510657
[Indexed for MEDLINE]

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