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Nat Rev Cancer. 2008 Jan;8(1):61-70.

Survivin, cancer networks and pathway-directed drug discovery.

Author information

1
Department of Cancer Biology and the Cancer Center, Lazare Research Building 428, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA. dario.altieri@umassmed.edu

Abstract

Although there is no shortage of potential targets for cancer therapeutics, we know of only a handful of molecules that are differentially expressed in cancer and intersect multiple pathways required for tumour maintenance. Survivin embodies these properties, and orchestrates integrated cellular networks that are essential for tumour cell proliferation and viability. Pursuing the nodal functions of survivin in cancer might lead to the development of global pathway inhibitors with unique therapeutic potential.

PMID:
18075512
DOI:
10.1038/nrc2293
[Indexed for MEDLINE]
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