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J Clin Endocrinol Metab. 2008 Mar;93(3):888-94. Epub 2007 Dec 11.

Thyroid function and lipid subparticle sizes in patients with short-term hypothyroidism and a population-based cohort.

Author information

1
Boston University Medical Center, Department of Biostatistics, Boston University School of Public Health, 88 East Newton Street, Evans 201, Boston, Massachusetts 02118, USA. elizabeth.pearce@bmc.org

Abstract

CONTEXT:

Relations between thyroid function and lipids remain incompletely understood.

OBJECTIVE:

Our objective was to determine whether lipoprotein subparticle concentrations are associated with thyroid status.

DESIGN AND SETTING:

We conducted a prospective clinical study and cross-sectional cohort analysis at a university endocrine clinic and the Framingham Heart Study.

SUBJECTS:

Subjects included 28 thyroidectomized patients with short-term overt hypothyroidism and 2944 Framingham Offspring cohort participants.

MAIN OUTCOME MEASURES:

Fasting subclass concentrations of very-low-density lipoprotein (VLDL), intermediate-density lipoprotein, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) particles were measured by nuclear magnetic resonance spectroscopy. TSH values were also measured.

RESULTS:

Total cholesterol and LDL-C were increased during short-term overt hypothyroidism. Large LDL subparticle concentrations increased during hypothyroidism (917+/-294 vs. 491+/-183 nmol/liter; P<0.001), but more atherogenic small LDL was unchanged. Triglycerides marginally increased during hypothyroidism, small VLDL particles significantly increased (P<0.001), whereas more atherogenic large VLDL was unchanged. Total HDL-C increased during hypothyroidism (76+/-13 mg/dl vs. 58+/-15 mg/dl; P<0.001). There was no change in large HDL-C particle concentrations, whereas small (P<0.001) and medium (P=0.002) HDL-C particle concentrations decreased. Among Framingham women, adjusted total cholesterol and LDL-C were positively related to TSH categories (P<or=0.003). This was due to a positive correlation between adjusted large LDL subparticle concentrations and log-TSH (P<0.0001); log small LDL subparticle concentrations decreased slightly as log-TSH increased (P=0.045). Among Framingham men, the only significant association was a positive association between log-TSH and log large HDL subparticle concentrations (P=0.04).

CONCLUSIONS:

There is a shift toward less atherogenic large LDL, small VLDL, and large HDL subparticle sizes in hypothyroid women.

PMID:
18073305
PMCID:
PMC2266946
DOI:
10.1210/jc.2007-1987
[Indexed for MEDLINE]
Free PMC Article

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