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Exp Clin Endocrinol Diabetes. 2008 Apr;116(4):211-4. Epub 2007 Dec 10.

The DG10S478 variant in the TCF7L2 gene is not associated with microvascular complications in type 2 diabetes.

Author information

1
Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany. Susanne.Buchbinder@med.uni-heidelberg.de

Abstract

OBJECTIVE:

The DG10S478 variant in the transcription factor 7-like 2 (TCF7L2) gene is a tetranucleotide repeat with six alleles. Alleles 0, 8 and 12 were found to account for 98% of chromosomes in population based controls. The composite allele X (non zero) has been associated with type 2 diabetes while allele 0 (no insertion) was described as protective. However, no data exist about the influence of DG10S478 variants on manifestation of diabetes and development of diabetic complications.

METHODS:

250 patients with type 2 diabetes were tested for the DG10S478 allele X and its association with diabetic complications, age at diagnosis of diabetes and BMI.

RESULTS:

Allele 0 was found in 42.4% of the examined patients, 45.2% of the participants were found to be heterozygous and 12.4% homozygous for the composite allele X. The correlation of allele X with the age at diagnosis of diabetes was not significant. There was also no association of allele X with retinopathy, nephropathy or neuropathy. Only the correlation with BMI was statistically significant.

CONCLUSIONS:

The DG10S478 variant seems to have no influence on manifestation of diabetes and the development of microvascular complications.

PMID:
18072015
DOI:
10.1055/s-2007-993149
[Indexed for MEDLINE]

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