Format

Send to

Choose Destination
See comment in PubMed Commons below
Chest. 2008 Aug;134(2):295-302. doi: 10.1378/chest.07-0141. Epub 2007 Dec 10.

Impact of cough across different chronic respiratory diseases: comparison of two cough-specific health-related quality of life questionnaires.

Author information

1
Regional Respiratory Centre, The Queen's University of Belfast, Northern Ireland.
2
Belfast City Hospital, Respiratory Research Group, The Queen's University of Belfast, Northern Ireland.
3
Department of Epidemiology and Public Health, The Queen's University of Belfast, Northern Ireland.
4
Department of Radiology, The Queen's University of Belfast, Northern Ireland.
5
Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.
6
Belfast City Hospital, Respiratory Research Group, The Queen's University of Belfast, Northern Ireland. Electronic address: l.mcgarvey@qub.ac.uk.

Abstract

BACKGROUND:

Cough is a prominent symptom across a range of common chronic respiratory diseases and impacts considerably on patient health status.

METHODS:

We undertook a cross-sectional comparison of scores from two cough-specific health-related quality of life (HRQoL) questionnaires, the Leicester Cough Questionnaire (LCQ), and the Cough Quality of Life Questionnaire (CQLQ), together with a generic HRQoL measure, the EuroQol. Questionnaires were administered to and spirometry performed on 147 outpatients with chronic cough (n = 83), COPD (n = 18), asthma (n = 20), and bronchiectasis (n = 26).

RESULTS:

There was no significant difference in the LCQ and CQLQ total scores between groups (p = 0.24 and p = 0.26, respectively). Exploratory analyses of questionnaire subdomains revealed differences in psychosocial issues and functional impairment between the four groups (p = 0.01 and p = 0.05, respectively). CQLQ scores indicated that chronic coughers have more psychosocial issues than patients with bronchiectasis (p = 0.03) but less functional impairment than COPD patients (p = 0.04). There was a significant difference in generic health status across the four disease groups (p = 0.04), with poorest health status in COPD patients. A significant inverse correlation was observed between CQLQ and LCQ in each disease group (chronic cough r = - 0.56, p < 0.001; COPD r = - 0.49, p = 0.04; asthma r = - 0.94, p < 0.001; and bronchiectasis r = - 0.88, p < 0.001). There was no correlation between cough questionnaire scores and FEV(1) in any group, although a significant correlation between EuroQol visual analog scale component and FEV(1) (r = 0.639, p = 0.004) was observed in COPD patients.

CONCLUSION:

Cough adversely affects health status across a range of common respiratory diseases. The LCQ and CQLQ can each provide important additional information concerning the impact of cough.

Comment in

PMID:
18071022
DOI:
10.1378/chest.07-0141
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center