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Antimicrob Agents Chemother. 2008 Feb;52(2):735-8. Epub 2007 Dec 10.

Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis.

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1
M. D. Anderson Cancer Center, University of Texas, Houston, Texas 77030-3930, USA. dkontoyi@mdanderson.org

Abstract

Synergistic interactions were observed between CIs and antifungal agents against 53 (90%) of 59 Cryptococcus neoformans isolates from solid organ transplant recipients with cryptococcosis and may account for better outcomes in patients with cryptococcosis receiving these immunosuppressive agents.

PMID:
18070977
PMCID:
PMC2224743
DOI:
10.1128/AAC.00990-07
[Indexed for MEDLINE]
Free PMC Article
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