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Br J Dermatol. 2008 Mar;158(3):603-6. Epub 2007 Dec 6.

Ichthyosiform erythroderma with rickets: report of five cases.

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Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi 110029, India.

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  • Br J Dermatol. 2008 Mar;158(3):657.


We describe five children with ichthyosis and rickets. The association of ichthyosis and rickets is very rare. Four children had lamellar ichthyosis and one child had nonbullous ichthyosiform erythroderma/psoriasis with atopy. All had biochemical and radiological evidence of rickets. Three had clinically evident rickets, of whom two had very severe skeletal deformities. Such a severe skeletal involvement due to rickets in association with ichthyosis is exceptionally rare. We suggest that children with severe ichthyosis, in particular those with pigmented skin, need to be evaluated for rickets, especially in developing countries where there is a background prevalence of vitamin D deficiency.

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