Format

Send to

Choose Destination
J Clin Virol. 2008 Jan;41(1):34-7.

Human bocavirus commonly involved in multiple viral airway infections.

Author information

1
Department of Medical Microbiology, St. Olavs Hospital, Trondheim University Hospital, Norway. andreas.christensen@stolav.no <andreas.christensen@stolav.no>

Abstract

BACKGROUND:

Human bocavirus (HBoV) was recently discovered in children with acute respiratory tract infections. We have included a PCR for HBoV in a study on airway infections in children.

OBJECTIVES:

To study the occurrence of HBoV in Norwegian children, and to evaluate the results of a semiquantitative PCR.

STUDY DESIGN:

During a 4-month period in the winter season 2006/2007 we collected nasopharyngeal aspirations from children who were admitted to the Department of Pediatrics. All samples were examined for 17 agents with real-time PCR.

RESULTS:

HBoV was detected in 45 of 376 samples (12%). The occurrence of HBoV was stable during the study period. Multiple viral infections were present in 78% of the samples (42% double, 20% triple and 16% quadruple infections). RS-virus, enterovirus and human metapneumovirus were the most frequently codetected agents. In samples with a high load for HBoV, significantly fewer multiple infections were found than in the other samples. Eighty-eight percent of the 25 patients with HBoV recorded as either the only or the dominating virus, and 50% of the other patients, had lower respiratory tract infection. The difference was statistically significant.

CONCLUSIONS:

HBoV was frequently detected in nasopharyngeal aspirates from children with airway infections in Norway. Multiple viral infections were common among the HBoV-infected patients. Semiquantitative PCR results may be useful for interpretation of clinical relevance.

PMID:
18069054
DOI:
10.1016/j.jcv.2007.10.025
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center