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Joint Bone Spine. 2008 May;75(3):325-8. Epub 2007 Oct 15.

Unexplained polyarthralgia and celiac disease.

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Rheumatology Federation, Lariboisière Teaching Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.


Celiac disease is an immunological disorder whose best-known manifestations are gastrointestinal symptoms. However, early joint manifestations are common and frequently overlooked features of celiac disease. We report a case in which unexplained inflammatory polyarthralgia and iron-deficiency anemia led to the diagnosis of celiac disease. Autoimmune thyroiditis was also a feature. Early diagnosis and treatment of celiac disease protect patients against complications such as digestive neoplasis. A simple and rapid tool for achieving the early diagnosis is the measurement of the serum of anti-gliadin, anti-endomysial and anti-tissue transglutaminase antibodies. However, a duodenal biopsy remains the only means of making the definitive diagnosis of celiac disease.

[Indexed for MEDLINE]

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