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Vaccine. 2008 Jan 10;26(2):158-65. Epub 2007 Nov 26.

Revaccination does not improve an observed deficit in antibody responses in Pakistani adults born of a lower birth weight.

Author information

1
MRC Keneba, Medical Research Council Laboratories, Fajara, P.O. Box 273, Banjul, Gambia. Sophie.Moore@lshtm.ac.uk <Sophie.Moore@lshtm.ac.uk>

Abstract

We have previously shown that the generation of antibodies to a polysaccharide vaccine (Typhim Vi) is compromised in Pakistani adults born of a lower birth weight. To assess whether this represents a true B-cell-dependent deficit, we revaccinated subjects with a second dose of the same vaccine and with a polysaccharide-protein conjugate vaccine to a different polysaccharide antigen (conjugated Haemophilus influenzae type b (Hib) vaccine). Anti-Vi IgG levels remained positively correlated with birth weight (p=0.0284) but no associations were observed between anti-Hib IgG levels and size at birth. These findings indicate that small size at birth results in a poor antibody response to vaccination with a polysaccharide antigen vaccine in adulthood, even following a second dose of the vaccine. No such association was observed in response to a polysaccharide-protein conjugate vaccine indicating an early-life programming effect on the generation of antibodies during a B-cell-dependent immune response.

PMID:
18068877
DOI:
10.1016/j.vaccine.2007.11.007
[Indexed for MEDLINE]

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