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Anal Chim Acta. 2008 Jan 7;606(1):92-7. Epub 2007 Nov 4.

Molecularly imprinted polymer using beta-cyclodextrin as functional monomer for the efficient recognition of bilirubin.

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  • 1Beijing National Laboratory for Molecular Sciences, The Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.


Bilirubin (BR) imprinted polymer was successfully prepared using supramolecular host compound beta-cyclodextrin (beta-CD) as functional monomer. The adsorption equilibrium was attained in about 4 h, which indicated that the adsorption kinetics was comparatively fast. The results of adsorption and selectivity experiments indicated that BR-imprinted beta-CD polymer was able to bind BR specifically and reversibly. The specific recognition of BR-imprinted beta-CD polymer for BR may be due to the cooperative effects of inclusion interaction and hydrogen bonding. This BR-imprinted beta-CD polymer was further applied to eliminate BR in human serum sample. It was verified that the binding specificity of the BR-imprinted polymer for BR was essentially sufficient in the presence of other compounds coexisting in serum sample. Therefore, as a reusable material possessing high affinity and selectivity, BR-imprinted beta-CD polymer has a potential application perspective as a clinical hemoperfusion material.

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