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Trends Cell Biol. 2008 Jan;18(1):1-4. Epub 2007 Dec 18.

Mitochondrial stress signaling: a pathway unfolds.

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1
Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.

Abstract

Disruption of protein homeostasis in mitochondria elicits a cellular response, which upregulates mitochondrial chaperones and other factors that serve to remodel the mitochondrial-folding environment. In a recent study, Haynes and colleagues uncovered a novel signal transduction pathway underlying this process. The upstream mitochondrial component of this pathway is an orthologue of Escherichia coli ClpP, which functions in the bacterial heat-shock response. These findings suggest that molecular aspects of stress sensing might be conserved between bacteria and mitochondria.

PMID:
18068368
DOI:
10.1016/j.tcb.2007.11.003
[Indexed for MEDLINE]
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