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Am J Obstet Gynecol. 2008 Mar;198(3):336.e1-5. Epub 2008 Feb 20.

Genetic association of preeclampsia to the inflammatory response gene SEPS1.

Author information

1
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA. moses@darwin.sfbr.org

Abstract

OBJECTIVE:

The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia.

STUDY DESIGN:

A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n = 1139) and control (n = 2269) women. Statistical significance was determined by chi2 and multivariate regression analyses.

RESULTS:

Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P = .0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P = .023; odds ratio, 1.22; 95% CI, 1.02 to 1.46).

CONCLUSION:

The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population.

PMID:
18068137
DOI:
10.1016/j.ajog.2007.09.024
[Indexed for MEDLINE]

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