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Reagents for the selective immobilization of oligonucleotides on solid supports.

Author information

1
Institute of Physical Organic Chemistry NAS, Minsk, Belarus.

Abstract

New reagents (CPGs and phosphoramidites) for automatic solid phase synthesis of modified oligonucleotides were designed. Three oligonucleotides carrying fluorescent label at the 5'-terminus and an anchor group at the 3'-terminus were prepared and their immobilization in orthogonal conditions on solid supports was studied.

PMID:
18066905
DOI:
10.1080/15257770701503670
[Indexed for MEDLINE]

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