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Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines.

Author information

1
College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@ewha.ac.kr

Abstract

Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6-9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from d-ribose. Cytosine analog 8 was found to exhibit significant anticancer activity in various human tumor cell lines.

PMID:
18066886
DOI:
10.1080/15257770701490852
[Indexed for MEDLINE]

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