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Nat Struct Mol Biol. 2008 Jan;15(1):103-5. Epub 2007 Dec 9.

Structural basis for the coevolution of a viral RNA-protein complex.

Author information

1
Department of Anatomy, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York 10461, USA.

Abstract

The cocrystal structure of the PP7 bacteriophage coat protein in complex with its translational operator identifies a distinct mode of sequence-specific RNA recognition when compared to the well-characterized MS2 coat protein-RNA complex. The structure reveals the molecular basis of the PP7 coat protein's ability to selectively bind its cognate RNA, and it demonstrates that the conserved beta-sheet surface is a flexible architecture that can evolve to recognize diverse RNA hairpins.

PMID:
18066080
PMCID:
PMC3152963
DOI:
10.1038/nsmb1327
[Indexed for MEDLINE]
Free PMC Article

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