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Nat Rev Immunol. 2008 Jan;8(1):74-80.

Creating immune privilege: active local suppression that benefits friends, but protects foes.

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Immunotherapy and Cancer Centers, Medical College of Georgia, Augusta, Georgia USA.

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  • Nat Rev Immunol. 2008 Feb;8(2):160.


Natural regulatory mechanisms prevent inappropriate immune activation to self and innocuous foreign antigens. Here, we adapt the notion of immune privilege, which was originally applied to transplanted tissues, to consider how antigenic tumour cells and chronic pathogens might exploit natural regulatory mechanisms to become non-immunogenic. This conceptual approach reveals new mechanistic perspectives that may help to explain the paradoxical persistence of tumours and chronic pathogens, and suggests new opportunities to improve immunotherapy to treat these chronic inflammatory diseases.

[Indexed for MEDLINE]

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