We report the case of a 54-year-old female who was found to have adenocarcinoma of the gall bladder 2 years after the onset of yellow discolouration and deformity of all 20 nails. She also exhibited a past history of chronic sinusitis and mild bronchiectasis. As the tumour was inoperable, palliative surgery was performed. This case adds further support to a possible association between malignancy and the yellow nail syndrome (YNS).