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Microbes Infect. 2007 Nov-Dec;9(14-15):1636-43. Epub 2007 Sep 14.

The Mx GTPase family of interferon-induced antiviral proteins.

Author information

1
Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, Hermann-Herderstrasse 11, D-79008 Freiburg, Germany. otto.haller@uniklinik-freiburg.de

Abstract

Mx proteins are interferon-induced members of the dynamin superfamily of large GTPases. They inhibit a wide range of viruses by blocking an early stage of the replication cycle. Studies in genetically defined mouse strains highlight their powerful action in early antiviral host defence.

PMID:
18062906
DOI:
10.1016/j.micinf.2007.09.010
[Indexed for MEDLINE]

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