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J Neurosci Methods. 2008 Mar 15;168(2):494-9. Epub 2007 Oct 30.

Assessing transient cross-frequency coupling in EEG data.

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Department of Epileptology and Center for Life and Brain, University of Bonn, Germany.


Synchronization of oscillatory EEG signals across different frequency bands is receiving waxing interest in cognitive neuroscience and neurophysiology, and cross-frequency coupling is being increasingly linked to cognitive and perceptual processes. Several methods exist to examine cross-frequency coupling, although each has its limitations, typically by being flexible only over time or over frequency. Here, a method for assessing transient cross-frequency coupling is presented, which allows one to test for the presence of multiple, dynamic, and flexible cross-frequency coupling structure over both time and frequency. The method is applied to intracranial EEG data, and strong coupling between gamma ( approximately 40-80 Hz) and upper theta ( approximately 7-9 Hz) was observed. This method might have useful applications in uncovering the electrophysiological correlates of cognitive processes.

[Indexed for MEDLINE]

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