The curative and antioxidative efficiency of doramectin and doramectin+vitamin AD3E treatment on Psoroptes cuniculi infestation in rabbits

Res Vet Sci. 2008 Oct;85(2):291-3. doi: 10.1016/j.rvsc.2007.10.005. Epub 2007 Dec 3.

Abstract

In the present study, the efficiency of the administration of doramectin (DOR) and DOR+vitamin AD3E (VIT), and the influence of these agents on oxidative stress parameters in rabbits infested by Psoroptes cuniculi (P. cuniculi) were investigated. DOR (200 microg/kg) and DOR (200 microg/kg)+VIT AD3E were administered to infested rabbits intramuscularly (IM). The administration of DOR and DOR+VIT improved the healing of ear lesions on day seven. Increase in the plasma malondialdehyde (MDA) level and erythrocyte catalase (CAT) activity, and decrease in glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities were determined in infested rabbits. In the rabbits which were administered DOR+VIT, plasma MDA levels decreased, and erythrocyte GSH-Px and SOD activities increased on day seven. In conclusion, DOR and DOR+VIT combination were effective against P. cunuculi infestation. Infestation stimulated oxidative stress. VIT treatment resulted in antioxidant activity against oxidative stress induced by P. cuniculi infestation.

MeSH terms

  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / therapeutic use
  • Drug Combinations
  • Drug Therapy, Combination
  • Insecticides / administration & dosage
  • Insecticides / therapeutic use
  • Ivermectin / administration & dosage
  • Ivermectin / analogs & derivatives*
  • Ivermectin / therapeutic use
  • Mite Infestations / drug therapy
  • Mite Infestations / veterinary*
  • Psoroptidae / drug effects
  • Rabbits*
  • Vitamins / administration & dosage*
  • Vitamins / therapeutic use*

Substances

  • Antioxidants
  • Drug Combinations
  • Insecticides
  • Vitamins
  • Ivermectin
  • doramectin