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Dev Cell. 2007 Dec;13(6):755-6.

Opposing effects of Wnt and MAPK on BMP/Smad signal duration.

Author information

1
Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada. everheye@sfu.ca

Abstract

Signaling downstream of BMP receptors relies on activated nuclear Smad proteins. Recent studies, one of which is published in the November 30 issue of Cell, shed light on a mechanism that balances inputs from both activated MAPK and Wnt pathways to regulate the proteasomal degradation of Smad1 and thus modulate the extent of BMP signaling.

PMID:
18061555
DOI:
10.1016/j.devcel.2007.11.006
[Indexed for MEDLINE]
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