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Curr Opin Cell Biol. 2007 Dec;19(6):691-6. Epub 2007 Dec 3.

The primary cilia, a 'Rab-id' transit system for hedgehog signaling.

Author information

1
Stanford University, School of Medicine, Stanford, CA 94305, USA. oro@stanford.edu

Abstract

Intense focus has been centered around how the primary cilia transduces the hedgehog (Hh) signal from smoothened (Smo) to the Gli transcription factors. New data indicate that ligand and signaling lipids help regulate small GTPase-dependent accumulation and activity of signaling components.

PMID:
18061425
PMCID:
PMC3761365
DOI:
10.1016/j.ceb.2007.10.008
[Indexed for MEDLINE]
Free PMC Article
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