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Am J Obstet Gynecol. 2007 Dec;197(6):610.e1-7.

Early pregnancy lipid concentrations and spontaneous preterm birth.

Author information

1
Department of Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. jmcst43@pitt.edu

Abstract

OBJECTIVE:

Women who deliver preterm infants may be at increased risk for cardiovascular disease, perhaps related to dyslipidemia.

STUDY DESIGN:

In a nested case control study of women with spontaneous preterm birth, cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides were evaluated. Lipid concentrations and gestational changes, as well as risk for preterm birth, were evaluated in women who delivered <34 (n = 23), >or=34-<37 (n = 67), and >or=37 weeks (n = 199).

RESULTS:

High cholesterol or triglycerides <or=15 weeks were associated with a 2.8-fold (1.0-7.9) and 2.0-fold (1.0-3.9) increased risk for preterm birth <34 weeks and >or=34-<37 weeks, respectively. Overweight women who delivered <34 weeks had particularly elevated early pregnancy concentrations of cholesterol and low-density lipoprotein; lean women with moderate preterm birth had elevated triglycerides. There was a reduced triglyceride response in the first half of pregnancy among women who delivered <34 weeks.

CONCLUSION:

Our results indicate the presence of dyslipidemia in women with spontaneous preterm birth.

PMID:
18060950
DOI:
10.1016/j.ajog.2007.04.024
[Indexed for MEDLINE]

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