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Bioorg Med Chem Lett. 2008 Jan 15;18(2):710-5. Epub 2007 Nov 21.

Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists.

Author information

1
Department of Medicinal Chemistry, Laboratoire GlaxoSmithKline, Centre de Recherches, 25-27 avenue du Qu├ębec, 91951 Les Ulis, France. nicolas. faucher@gsk.com

Abstract

Starting from the structure of 5, a two-step strategy was applied to identify a new generation of trifluoromethane sulfonamides as potent PPARalpha agonists. Synthesis, in vitro and in vivo evaluation of the most potent compound are reported.

PMID:
18060776
DOI:
10.1016/j.bmcl.2007.11.053
[Indexed for MEDLINE]

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