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Nat Rev Mol Cell Biol. 2008 Feb;9(2):177-82. doi: 10.1038/nrm2309.

Smc5/6: a link between DNA repair and unidirectional replication?

Author information

1
Johanne M. Murray and Antony M. Carr are at the Genome Damage and Stability Centre, University of Sussex, Brighton, Sussex, BN1 9RQ, UK. a.m.carr@sussex.ac.uk

Abstract

Of the three structural maintenance of chromosome (SMC) complexes, two directly regulate chromosome dynamics. The third, Smc5/6, functions mainly in homologous recombination and in completing DNA replication. The literature suggests that Smc5/6 coordinates DNA repair, in part through post-translational modification of uncharacterized target proteins that can dictate their subcellular localization, and that Smc5/6 also functions to establish DNA-damage-dependent cohesion. A nucleolar-specific Smc5/6 function has been proposed because Smc5/6 yeast mutants display penetrant phenotypes of ribosomal DNA (rDNA) instability. rDNA repeats are replicated unidirectionally. Here, we propose that unidirectional replication, combined with global Smc5/6 functions, can explain the apparent rDNA specificity.

PMID:
18059412
DOI:
10.1038/nrm2309
[Indexed for MEDLINE]

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