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Pediatr Blood Cancer. 2008 Mar;50(3):692-4.

World disparities in risk definition and management of retinoblastoma: a report from the International Retinoblastoma Staging Working Group.

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  • 1Hospital JP Garrahan, Buenos Aires, Argentina and International Outreach Program, St Jude Children's Research Hospital, Memphis, Tennessee, USA.


Following from the publication of the International Retinoblastoma Staging System, an open internet discussion group was created at the resource. The results of a survey distributed among participants are discussed. Although most patients with retinoblastoma were treated under prospective protocols, there was a wide variation in the definition of risk criteria and in the criteria for giving adjuvant chemotherapy following enucleation. Definition of high-risk histological features and the criteria for use of adjuvant therapy will be standardized in future studies. Internet meetings are a valuable mechanism for enabling participation from under-resourced countries in the development of cooperative studies.

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