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Different strategies for the synthesis of 2'-O-aminoethyl adenosine building blocks.

Author information

1
Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.

Abstract

The chemical modification of the 2'-O-position of nucleosides proved to be of great importance for the RNA stability. Greater stability of RNA duplexes allows a longer half life in the cell and, therefore, a better effect of RNA Interference. Here we investigated the synthesis of 2'-O-aminoethyl adenosine as a cationic modified building block.

PMID:
18058499
DOI:
10.1080/15257770701505295
[Indexed for MEDLINE]

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