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Endocr Pathol. 2007 Fall;18(3):187-9.

Functional oncocytic adrenocortical carcinoma.

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1
Department of Pathology, Sunnybrook Health Science Centre, 2075 Bayview Avenue, Room E-432, Toronto, ON, M4N 3M5, Canada.

Abstract

We present a case of oncocytic adrenocortical carcinoma in a 25-year-old man who presented with persistent hypertension, hypokalemia, and a large right adrenal mass. Clinical workup revealed increased serum aldosterone level, suppressed serum ACTH level and high 24-h urine cortisol. Histologically the tumor showed several features of malignancy and electron microscopy confirmed oncocytic differentiation. This case is reported as the first case of an aldosterone and cortisol-producing malignancy with an oncocytic phenotype.

PMID:
18058268
DOI:
10.1007/s12022-007-9000-4
[Indexed for MEDLINE]
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