Format

Send to

Choose Destination
See comment in PubMed Commons below
MAGMA. 2007 Dec;20(5-6):255-64. Epub 2007 Dec 5.

Functional MRI at 3T using intermolecular double-quantum coherence (iDQC) with spin-echo (SE) acquisitions.

Author information

1
Department of Imaging Sciences, University of Rochester, Rochester, NY 14642, USA.

Abstract

OBJECT:

To reinvestigate the dependence of the signal and contrast on sequence parameters and tissue relaxation times for intermolecular double-quantum coherence (iDQC) signals, and to explore the possibility to use a spin-echo (SE)-iDQC sequence for detecting activation signals at 3T.

MATERIALS AND METHODS:

Brain activations were detected in five human volunteers in a visual simulation study using a SE-iDQC sequence, in addition to a GE-iDQC and a conventional single-quantum coherence (SQC) blood-oxygenation-level-dependent (BOLD) sequence. A brain phantom was also used for some quantitative measurements.

RESULTS:

By choosing an optimal echo time TE (approximately T2) and iDQC evolution time tau(approximately 20 ms), robust brain activations were detected using the SE-iDQC sequence, in addition to the GE-iDQC and a conventional single-quantum coherence (SQC) BOLD sequence. A higher percentage signal change due to activation was observed for both the iDQC-based measurements in comparison to the conventional SQC acquisition.

CONCLUSION:

Even though a phenomenological analysis consistent with the experimental results was provided, a detailed model is still needed for the contrast mechanism at microscopic level to guide potential applications of brain functional imaging based on the SE-iDQC.

PMID:
18057974
DOI:
10.1007/s10334-007-0093-z
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center