Send to

Choose Destination
See comment in PubMed Commons below
Hong Kong Med J. 2007 Dec;13(6):485-9.

Sequential non-traumatic femoral shaft fractures in a patient on long-term alendronate.

Author information

Department of Orthopaedics and Traumatology, Caritas Medical Centre, Shamshuipo, Hong Kong.


Fractures associated with osteoporosis are common among elderly people and postmenopausal women. Bisphosphonate is an effective anti-resorptive drug commonly used for the prevention and treatment of osteoporosis. There are, however, concerns about potential side-effects during long-term treatment with alendronate. We report a case where an 82-year-old woman who had been taking alendronate for 10 years presented with two episodes of non-traumatic femoral shaft fracture. An iliac bone biopsy showed severely suppressed bone turnover, suggestive of adynamic bone disease. We suspect the bone turnover suppression was related to the prolonged use of alendronate.

[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Hong Kong Academy of Medicine Press
    Loading ...
    Support Center