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Glycobiology. 2008 Feb;18(2):145-51. Epub 2007 Dec 3.

Neural complex-specific expression of xylosyl N-glycan in Ciona intestinalis.

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Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.


We herein report N-glycosylation profiles of the individual tissues derived from the ascidian Ciona intestinalis. Multidimensional HPLC mapping revealed that the C. intestinalis expresses high-mannose-type oligosaccharides as major N-glycans, along with paucimannose-type and complex-type oligosaccharides, in a tissue-specific manner. Notably, the trimannosyl core carrying beta1,2-xylose and alpha1,3-fucose residues was identified as a principal N-glycan in the neural complex. As far as we know, this is the first description of xylosyl N-glycan expressed in deuterostome. Furthermore, we found that this xylosyl N-glycan is exclusively displayed on a membrane-associated protein so far described as a putative protein whose gene expression is specific for the neural complex. These data suggested that the xylosyl N-glycan is associated with some neural functions of C. intestinalis.

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