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Antimicrob Agents Chemother. 2008 Feb;52(2):767-9. Epub 2007 Dec 3.

In vitro activities of voriconazole, itraconazole, and terbinafine alone or in combination against Pythium insidiosum isolates from Brazil.

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1
Campus UFSM, Prédio 20, Sala 4139, 97105-900 Santa Maria, RS, Brazil. santurio@smail.ufsm.br.

Abstract

We evaluated the in vitro activities of voriconazole, itraconazole, and terbinafine against 30 clinical isolates of Pythium insidiosum using a checkerboard macrodilution method. The combined activity of terbinafine plus itraconazole or plus voriconazole was synergic against 17% of the strains. Antagonism was not observed.

PMID:
18056274
PMCID:
PMC2224725
DOI:
10.1128/AAC.01075-07
[Indexed for MEDLINE]
Free PMC Article
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