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FEBS Lett. 2007 Dec 22;581(30):5904-10. Epub 2007 Dec 3.

A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion.

Author information

1
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-2200, USA.

Abstract

A thorough understanding of histone acetyltransferase CBP/p300-mediated regulation of gene expression and cell growth is essential to identify mechanisms relevant to the development of histone deacetylase (HDAC) inhibitor-based preventive and therapeutic strategies. We found that knockdown of CBP/p300 interacting coactivator with glutamic acid/aspartic acid-rich tail 2 (CITED2) increased colon cancer cell invasiveness in vitro. Gene expression profiling revealed that CITED2 knockdown induced matrix metalloproteinase-13 (MMP-13) gene expression in colon cancer cells. Butyrate, a naturally occurring HDAC inhibitor, induced CITED2 expression and downregulated MMP-13 expression in RKO cells. Additionally, ectopic expression of CITED2 arrested RKO cell growth. Thus, CITED2 regulates colon cancer invasion and might be a target for HDAC inhibitor-based intervention of colon cancer.

PMID:
18054336
PMCID:
PMC2211427
DOI:
10.1016/j.febslet.2007.11.072
[Indexed for MEDLINE]
Free PMC Article

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