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Bioorg Med Chem Lett. 2008 Jan 15;18(2):842-4. Epub 2007 Nov 13.

Inhibiting dihydrodipicolinate synthase across species: towards specificity for pathogens?

Author information

1
School of Chemistry, University of Melbourne, Vic. 3010, Australia.

Abstract

Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and an important antibiotic target. The specificity of a range of heterocyclic product analogues against DHDPS from three pathogenic species, Bacillus anthracis, Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus, and the evolutionarily related N-acetylneuraminate lyase, has been determined. The results suggest that the development of species-specific inhibitors of DHDPS as potential antibacterials is achievable.

PMID:
18054225
DOI:
10.1016/j.bmcl.2007.11.026
[Indexed for MEDLINE]

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