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Vaccine. 2007 Dec 12;25(51):8637-41. Epub 2007 Aug 13.

The impact of a new universal infant and school-based adolescent hepatitis B vaccination program in Australia.

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  • 1Centre for Infectious Diseases and Microbiology, Public Health and Institute of Clinical Pathology and Medical Research Building, 3rd Floor, Westmead Hospital, Westmead, New South Wales 2145, Australia.


We compared the results of two national serosurveys in Australia to evaluate the impact of universal infant vaccination and school-based programs for adolescents. Immunity improved significantly overall, especially in 1-year-olds (40.0% versus 86%; p<0.0001); in adolescents it was significantly higher in regions with established school-based programs (56.6% versus 38.8%; p=0.0008). 6.1% of 1-59-year-olds were positive for HBcAb and 0.7% for HBsAg. We have demonstrated successful implementation of universal infant hepatitis B vaccination in Australia and that school-based programs for adolescents are effective. This experience should be applicable to low prevalence countries in northern Europe which have not implemented universal hepatitis B immunisation.

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