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J Am Vet Med Assoc. 2007 Dec 1;231(11):1688-91.

Risk factors for excessive tibial plateau angle in large-breed dogs with cranial cruciate ligament disease.

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1
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.

Abstract

OBJECTIVE:

To identify risk factors for development of excessive tibial plateau angle (TPA) in large-breed dogs with cranial cruciate ligament disease (CCLD).

DESIGN:

Case-control study.

ANIMALS:

58 dogs with excessive TPAs (ie, TPA >or= 35 degrees ; case dogs) and 58 dogs with normal TPAs (ie, TPA <or= 30 degrees ; control dogs).

PROCEDURES:

Medical records and radiographs were reviewed and owners were interviewed to identify potential risk factors for excessive TPA.

RESULTS:

Case dogs were 3 times (95% confidence interval, 1.2 to 8.0) as likely to have been neutered before 6 months of age as were control dogs. Case dogs with TPA >or= 35 degrees in both limbs were 13.6 times (95% confidence interval, 2.72 to 68.1) as likely to have been neutered before 6 months of age as were control dogs with TPA <or= 30 degrees in both limbs. Case dogs were significantly younger at the onset of hind limb lameness than were control dogs.

CONCLUSIONS AND CLINICAL RELEVANCE:

Results suggested that early neutering was a significant risk factor for development of excessive TPA in large-breed dogs with CCLD. Further research into the effects of early neutering on TPA and the pathophysiology of CCLD is warranted.

PMID:
18052804
DOI:
10.2460/javma.231.11.1688
[Indexed for MEDLINE]
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