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J Periodontol. 2007 Dec;78(12):2380-4.

Sudden improvement of insulin sensitivity related to an endodontic treatment.

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  • 1Institute of Sports Medicine, University of Leipzig, Leipzig Sachsen, Germany. A.Schulze@uni-leipzig.de

Abstract

BACKGROUND:

Inflammation contributes to the pathogenesis of diabetes. A reciprocal relationship exists between diabetes and chronic periodontitis. This report describes the effects of an acute focal dental inflammation and subsequent endodontic treatment on the required insulin dosage of a 70-year-old man who had moderately controlled diabetes.

METHODS:

Following an exacerbation of a combined endodontic-periodontic (endo-perio) lesion of tooth #3, the patient noticed a sudden increase in his insulin demand. After 3 weeks, the required dosage was approximately 100% greater. In association with hyperglycemic incidents, he reported a prickling sensation in this tooth. The radiograph showed circular bone loss around the tooth.

RESULTS:

Just 1 day after the root-canal preparation, the insulin need decreased to approximately 50% of that required prior to treatment. Subsequently, an incision and systemic antibiotics were necessary because of the formation of a periodontal abscess. The insulin demand remained low despite this complication. Forty days after endodontic treatment, the insulin dosage was at a level comparable to that taken 4 weeks before the root-canal preparation.

CONCLUSIONS:

This clinical case revealed a highly relevant correlation between insulin resistance and a local dental inflammation. To avoid an increase in insulin resistance, it seems important to attend to radically non-vital teeth as well as any other dental inflammation in diabetic patients.

PMID:
18052712
DOI:
10.1902/jop.2007.070033
[PubMed - indexed for MEDLINE]
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