Format

Send to

Choose Destination
See comment in PubMed Commons below
Langmuir. 2008 Jan 1;24(1):239-44. Epub 2007 Dec 1.

Magnetic-sensitive silica nanospheres for controlled drug release.

Author information

1
Department of Materials Sciences and Engineering, National Chiao Tung University, 1001 Ta Hsueh Road, Hsinchu, Taiwan, Republic of China.

Abstract

Recently, magnetic silica-based nanospheres have received great attention and displayed magnificent potential for bioimaging and therapeutic purposes. This study provided a way to accelerate drug release from magnetic-sensitive silica nanospheres by controlled bursting to a therapeutically effective concentration by a high-frequency magnetic field (HFMF). The magnetic-sensitive silica nanospheres were synthesized by an in situ process, with particle sizes about 50 nm and able to release specific amounts of drug in a burst manner via short exposure to a HFMF. The HFMF accelerates the rotation of magnetic nanoparticles deposited in the silica matrix with generated heat energy and subsequently enlarges the nanostructure of the silica matrix to produce porous channels that cause the drug to be released easily. By taking these magnetic-responsive controllable drug release behaviors, the magnetic silica nanospheres can be designed for controlled burst release of therapeutic agents for especially urgent physiological needs.

PMID:
18052081
DOI:
10.1021/la701570z
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Support Center