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Br J Dermatol. 2008 Jan;158(1):15-21. Epub 2007 Nov 28.

Genetics of melanoma tumorigenesis.

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Department of Dermatology, Harvard Medical School, Boston, MA 02114, USA.


Melanoma therapy is moving away from combinatorial approaches and towards newer targeted strategies. With the identification of mutations in various RAS pathway genes, there are now tremendous opportunities to bring inhibitors of RAS signalling to the clinical arena.

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