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Eur J Clin Pharmacol. 1991;41(4):355-7.

Pharmacokinetics of midazolam in children: comparative study of intranasal and intravenous administration.

Author information

1
Département de Pharmacologie Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Paris, France.

Abstract

Twelve children 1-5 y old were randomly assigned to receive midazolam 0.2 mg.kg-1 either by the intravenous (IV) or intranasal (IN) routes. After IN administration the rapid onset of absorption was observed (tmax 12 min). After both routes of administration the half-life was similar (2.2 h IN and 2.4 h IV). After IN administration the apparent plasma clearance and volume of distribution were about twice as high as after IV administration. The results are consistent with an estimated mean bioavailability of 55%.

PMID:
1804652
DOI:
10.1007/BF00314967
[Indexed for MEDLINE]

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