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J Perinatol. 2008 Feb;28(2):97-101. Epub 2007 Nov 29.

Amnioinfusion in preterm PROM: effects on amnion and cord histology.

Author information

1
Department of Obstetrics and Gynecology, University of Milano-Bicocca, Monza, Italy. anna.locatelli@unimib.it

Abstract

OBJECTIVE:

To investigate the effects of transabdominal amnioinfusion (TA) on the histology of amnion (A) and umbilical cord (UC).

STUDY DESIGN:

From a cohort of 56 singleton pregnancies with premature rupture of membranes (PROM) at <or=24.6 weeks, we excluded those who did not develop severe oligohydramnios (n=12). Of the 44 patients, 29 consented to TA and 15 declined the procedure. TA was performed with normal saline solution.

RESULT:

Women who consented to TA underwent a median of three procedures had a gestational age at PROM of 18.7 weeks and at delivery of 26.1 weeks, with a latency of 50 days. Compared with subjects who declined the procedure, TA had a beneficial effect on clinical variables, mediated primarily by a longer latency. TA was not associated with identifiable effects on the histologic features of A or UC.

CONCLUSION:

A and UC histology is not significantly affected by exposure to saline solution even for prolonged periods of time.

PMID:
18046340
DOI:
10.1038/sj.jp.7211876
[Indexed for MEDLINE]

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